Tandem repeats are segments of DNA in which short nucleotide motifs are repeated in contiguous blocks. These repeated sequences—particularly short tandem repeats (STRs) composed of 1–6 base pair ...

Engineered T cell therapies involve the genetic modification of a patient’s own immune cells with chimeric antigen receptors (CARs). When re-introduced into the patient, these engineered CAR-T cells ...

Experience of seven Spanish centres with echoendoscopically implanted 32P microparticles associated with chemotherapy in locally advanced pancreatic adenocarcinoma. This is an ASCO Meeting Abstract ...

So-called junk DNA was given that unfortunate nickname because its function was so mysterious. These vast regions of the genome do not code for protein and are made up of highly repetitive sequences.

Expanded repetitive sequences are infamous for causing inherited disease. Think poly-Q tracts that cause Huntington’s or the C9orf72 hexanucleotide run-ons that trigger ALS/FTD. However, given people ...

Researchers have built the first genetic reference map for tandem repeat expansions, a critical tool for congenital disease research. Researchers at the University of California, Irvine (CA, USA) have ...